Product information:
| Product name |
Griseofulvin Tablets |
| Specification |
500mg |
| Storage |
Dry Cool Place |
| Shelf life |
3 Years |
Indication:
This product is suitable for the treatment of tinea capitis, tinea mentagrophytes, tinea corporis, tinea cruris, tinea pedis and tinea onychomycosis. The above-mentioned tinea diseases are caused by deep red Trichophyton, Trichophyton interrupted, Trichophyton beard, Trichophyton interphalangeum, as well as Microsporum audouan, Microsporum canis, Microsporum gypsophilum and Epidermophyton flocculus.
This product is not suitable for mild, limited superficial fungal infection and local use of antifungal drugs has been effective. Griseofulvin had no effect on Candida, Histoplasma, actinomycetes, Sporothrix, Blastomyces, coccidium, Nocardia and Cryptococcus, and tinea versicolor.
Adverse reactions:
1. Nervous system headache is more common, about 10% of patients may have headache, which is severe at the beginning, and can be relieved by continuous medication. Others are drowsiness and fatigue. Occasionally vertigo, ataxia and peripheral neuritis occurred.
2.Mild or a few patients with upper abdominal discomfort.
3. About 3% of the patients with allergic reaction may have skin rash, occasionally angioneurotic edema, persistent urticaria, exfoliative dermatitis, and a few patients may have photosensitive dermatitis.
4. This product can cause peripheral leucopenia, hepatotoxicity and proteinuria occasionally.
Matters needing attention:
1. Cross allergy because griseofulvin was obtained from Penicillium, it is speculated that griseofulvin may have cross allergy with penicillins or penicillamine. However, this situation has not been confirmed clinically, but patients with penicillin allergy still need to be cautious and closely observed.
2. Griseofulvin can induce tumor in animal experiments.
3. This product can cause hepatotoxicity occasionally. Patients with original liver disease or liver function damage need to weigh the advantages and disadvantages before deciding whether to use it.
4. This product can induce porphyria and lupus erythematosus. If lupus erythematosus patients have indications, it must be decided after weighing the advantages and disadvantages.
5. The peripheral blood picture, liver function, blood urea nitrogen, creatinine and urine routine should be detected regularly during the treatment.
6. This product can be taken at the same time or after meals, and high fat meal is the best, because it can reduce gastrointestinal reactions and increase drug absorption.
7. In order to prevent recurrence, the treatment should continue until the clinical symptoms disappear and the laboratory examination proves that the pathogen has been completely eradicated. The general course of treatment is: tinea capitis 8-10 weeks; tinea corporis 2-4 weeks; tinea pedis 4-8 weeks; tinea fingernail at least 4 months; tinea toenail at least 6 months; but the recurrence rate of tinea toenail is still high.
8. It is usually necessary to give appropriate local medication at the same time, which is particularly important for tinea pedis.
9. Male patients should take contraceptive measures during and at least 6 months after treatment.
Pharmacology and Toxicology:
This product has good antibacterial effect on Trichophyton, Microsporum, epidermis and other superficial fungi. It has no antibacterial effect on Candida, Cryptococcus, histoplasmon, Sporothrix, Blastomyces and coccidiospores. It inhibits the growth of fungi by interfering with the synthesis of nucleic acid.
Pharmacokinetics:
The oral absorption of this product varies with different preparations. The microparticle type of this drug can be absorbed by 25% - 70%, and the ultramicroparticle type can be absorbed almost completely after oral administration. Eating fat can significantly increase the degree of absorption. The serum protein binding rate is about 80%. After absorption, the product can deposit in the cuticle of skin, hair and nail, and combine with its keratin to prevent the invasion of sensitive dermatophytes. The pathogenic fungi existing in the superficial cuticle leave the human body with the shedding of skin or hair, and only a small amount is distributed to other body fluids and tissues. It can also enter fetal circulation and secrete from milk. The main metabolites are 6-methylgriseofulvin and its glyoxal acylate. The elimination half-life (T1 / 2 β) of serum is 14-24 hours. Less than 1% of the drug was excreted from urine in its original form, and about 16% - 36% of the drug was excreted from feces in its original form.
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