Diclofenac Sodium Suppository
Warning:
The liver and kidney function should be routinely followed up during medication.
Ingredients:
The main component is diclofenac sodium.
Category:
Chemical and Biological Products > > nervous system drugs > > anti migraine drugs
Chemical and Biological Products > > antipyretic, analgesic and anti-inflammatory drugs > > organic acids > > carboxylic acids
character:
This product is white or light yellow.
indication:
Anti inflammatory and analgesic drugs. For rheumatoid arthritis, postoperative pain and fever caused by various reasons.
Usage and dosage:
Take out the suppository, moisten it with a small amount of warm water, and gently insert it into the anus 2cm away. For adults, take one suppository at a time, 1-2 times a day, or follow the doctor's advice.
Adverse reactions were as follows
Gastrointestinal reaction: the main symptoms are anal irritation, stomach discomfort, burning sensation, acid regurgitation, anorexia, nausea, etc., which will disappear after withdrawal or symptomatic treatment. A few of them may have ulcer, bleeding and perforation;
Neurological manifestations included headache, vertigo, drowsiness, excitement, etc;
Kidney causes edema, oliguria, electrolyte disorder and other serious renal adverse reactions;
Other rare cases were transient elevation of liver enzymes, jaundice, rash, arrhythmia, neutropenia, thrombocytopenia and so on.
Taboo:
Patients known to be allergic to this product.
Patients with asthma, urticaria or allergic reactions after taking aspirin or other non steroidal anti-inflammatory drugs.
It is forbidden to treat perioperative pain during coronary artery bypass grafting (CABG).
Patients with a history of gastrointestinal bleeding or perforation after the use of NSAIDs.
Patients with active peptic ulcer / bleeding or previous recurrent ulcer / bleeding.
Patients with severe heart failure.
matters needing attention:
Avoid combination with other NSAIDs, including selective COX-2 inhibitors.
According to the need of controlling symptoms, the use of the lowest effective dose in the shortest treatment time can minimize the adverse reactions.
Gastrointestinal bleeding, ulcers and perforation can occur at any time during the treatment with all NSAIDs, and the risk can be fatal. These adverse reactions may or may not be accompanied by warning symptoms, regardless of whether the patient has a history of gastrointestinal adverse reactions or serious gastrointestinal events. Patients with previous gastrointestinal history (ulcerative colitis, Crohn's disease) should be cautious in the use of non steroidal anti-inflammatory drugs, so as not to worsen the disease. The drug should be stopped when gastrointestinal bleeding or ulcer occurs. The frequent increase of adverse reactions in elderly patients using NSAIDs, especially gastrointestinal bleeding and perforation, may be fatal.
Clinical trials of COX-2 selective or non selective NSAIDs with a duration of up to 3 years show that this product may increase the risk of serious cardiovascular thrombotic adverse events, myocardial infarction and stroke, and its risk may be fatal. All NSAIDs, including COX-2 selective or non selective drugs, may have similar risks. Patients with cardiovascular disease or cardiovascular risk factors have a higher risk. Doctors and patients should be alert to such events even if they have no previous cardiovascular symptoms. The patient should be informed of the symptoms and / or signs of severe cardiovascular safety and the steps to be taken if they occur. Patients should be alert to symptoms and signs such as chest pain, shortness of breath, weakness and vagueness of speech, and should seek medical help immediately after any of the above symptoms or signs occur.
Like all non steroidal anti-inflammatory drugs (NSAIDs), this product can cause new onset hypertension or aggravate existing hypertension symptoms, any of which can increase the incidence of cardiovascular events. When patients taking thiazides or loop diuretics take non steroidal anti-inflammatory drugs (NSAIDs), the efficacy of these drugs may be affected. Patients with hypertension should be cautious in the use of non steroidal anti-inflammatory drugs (NSAIDs), including this product. Blood pressure should be closely monitored at the beginning and throughout the treatment.
Patients with hypertension and / or heart failure * such as fluid retention and edema should be cautious.
NSAIDs, including this product, may cause fatal and serious skin adverse reactions, such as exfoliative dermatitis, Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (ten). These serious events can occur without warning. Patients should be informed of the symptoms and signs of severe skin reactions, and discontinue the product when skin rashes or other signs of allergic reactions appear for the first time.
Medication for pregnant and lactating women:
This product can pass through placenta and animal test. It is toxic to fetal rats, but it is not teratogenic. Pregnant women should use it with caution.
Medication for children:
This specification is not suitable for children.
Medication for the elderly:
The liver and kidney function should be routinely followed up during medication.
Drug interactions:
Alcohol consumption or use with other NSAIDs can increase gastrointestinal side effects and risk ulceration. Long term use with acetaminophen can increase the toxic and side effects on kidney.
When used together with aspirin or other salicylic acid drugs, the efficacy did not increase, but the incidence of gastrointestinal adverse reactions and bleeding tendency increased.
When used together with anticoagulants such as heparin, dicoumarin and platelet aggregation inhibitors, it may increase the risk of bleeding.
When used together with furosemide, the sodium excretion and antihypertensive effect of furosemide were weakened.
When used together with verapamil and nifedipine, the blood concentration of the drug increased.
This product can increase the blood concentration of digoxin. Attention should be paid to adjust the dosage of digoxin.
When used together with antihypertensive drugs, it can affect the antihypertensive effect of the latter.
Probenecid can reduce the excretion of the product, increase the blood concentration and increase the toxicity, so it is appropriate to reduce the dosage of the product when used together.
This product can reduce the excretion of methotrexate, increase its blood concentration, even reach the toxic level, so this product should not be used with medium or large dose methotrexate.
| Suppository |
Specifications |
| Acetaminophen Suppository |
1.8g/granule |
| Artemether Suppository |
1.8g/granule |
| Diclofenac Suppository |
1.8g/granule |
| Indomethacin Suppository |
100mg |
| Ketoprofen Suppository |
1.8g/granule |
| Tinidazole Suppository |
0.2g |
| Wasong Pessary Suppository |
5g/8g |
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