Uses of Colchicine Tablets:
- It is used to treat gout attacks.
- It is used to prevent gout attacks.
- It is used to treat familial Mediterranean fever.
- It may be given to you for other reasons. Talk with the doctor.
What are some things I need to know or do while I take Colchicine Tablets?
- Tell all of your health care providers that you take this medicine (colchicine tablets). This includes your doctors, nurses, pharmacists, and dentists.
- This medicine interacts with many other drugs. The chance of side effects may be raised. This may include severe, life-threatening, or deadly side effects. Check with your doctor and pharmacist to make sure that it is safe for you to take this medicine (colchicine tablets) with all of your other drugs (prescription or OTC, natural products, vitamins).
- Avoid grapefruit and grapefruit juice.
- Deadly overdoses have happened with this medicine (colchicine tablets) in adults and children. Keep away from children. Do not take more than you were told. If this drug is taken by accident, call your poison control center or get medical care right away.
- Some males have had sperm problems while taking this medicine (colchicine tablets). This may affect being able to father a child. This may go back to normal after the drug is stopped. Talk with the doctor.
- If you are 65 or older, use this medicine (colchicine tablets) with care. You could have more side effects.
- Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Numbness or tingling in the hands or feet.
- Pale skin.
- Very bad muscle problems have happened with this medicine (colchicine tablets). This can also lead to kidney problems. Tell your doctor if you have muscle pain or weakness, especially if you feel very tired or weak or have a fever. Tell your doctor if you are not able to pass urine or you have a change in how much urine is passed.
- Low blood cell counts have happened with this medicine (colchicine tablets). If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. Call your doctor right away if you have signs of infection like fever, chills, or sore throat; any unexplained bruising or bleeding; or if you feel very tired or weak.
What are some other side effects of Colchicine Tablets?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Stomach pain or diarrhea.
- Upset stomach or throwing up.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
Pharmacology and Toxicology
Colchicine can change the function of cell membrane by binding with the subunits of neutrophil tubulin, including inhibiting the chemotaxis, adhesion and phagocytosis of neutrophils; inhibiting phospholipase A, reducing the release of prostaglandins and leukotrienes from monocytes and neutrophils; inhibiting the production of interleukin by local cells, so as to control local pain, swelling and inflammation of joints Symptomatic reaction. Colchicine does not affect the formation, dissolution and excretion of urate, so it has no effect on lowering blood uric acid. Acute gouty arthritis takes effect 12-24 hours after oral administration, and 90% of the patients have no pain in 24-48 hours.
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