Efficacy of decoction pieces
The substance has the following effects: it can protect liver cells from the invasion of toxic substances, especially alcohol and environmental pollutants (pesticides, heavy metals, etc.); it has strong antioxidant function, can protect liver cells from free radical damage, far more effective than vitamin E; it can promote the synthesis of protein, speed up the production of new liver cells, or make damaged liver cells fine The cells repair themselves. Therefore, it is called "natural liver protecting medicine". In addition, silymarin has the effects of anti radiation, anti-aging, prevention and treatment of arteriosclerosis, delaying skin aging and so on. The product is widely used in the production of medicine, health care products, cosmetics, food and other products. At present, silymarin has oral preparations: silymarin tablets, Yiganling tablets, silybin lecithin complex hard capsules. The trade names are: Liganlong, Liganlong, Yiganling, etc. Injections are mainly made of silybin derivatives, such as glu-n · methylamine salt.
Silymarin 2,3-dihydro-3 - (4-hydroxy-3-methoxyphenyl) - 2-hydroxymethyl-6 - (3,5,7-trihydroxy-4-oxobenzopyran-2-yl) benzodioxane
Silymarin is a kind of flavonoid lignans derived from the condensation of dihydroflavonol and phenylpropanoid derivatives extracted from the fruits and seeds of Silybum marianum (L) gaenrt, a herbaceous plant of Compositae. At present, silymarin is widely used in pharmaceutical preparations in the world The content of total flavonoid lignans in thistle is about 80%, which mainly contains silybin (silibinin), isosilybin (isosilibinin), silihristin (silihristin), silidinin (silidinin). Among them, silibinin has the highest content and hepatoprotective activity
Indication:
This product has inhibitory effect on lipoxygenase and peroxidase. Clinically, it is used in the treatment of hepatotoxicity, liver dysfunction, anti radiation and hypolipidemic effect.
A large number of studies have shown that silymarin and silybin have a wide range of pharmacological activities
Scavenging reactive oxygen species
It can directly eliminate reactive oxygen species, resist lipid peroxidation and maintain the fluidity of cell membrane;
Hepatoprotective effect
Silymarin has protective effect on liver damage caused by carbon tetrachloride, galactosamine, alcohols and other hepatotoxins;
antitumor activity
All kinds of reactive oxygen species can oxidize guanine to form 8-hydroxyguanine, which can cause DNA damage and then cause tumor. Antioxidants, especially free radical scavengers, can prevent this process;
Anti cardiovascular effects
Protective effect on cerebral ischemia injury
Pharmacological action:
It has been proved that silymarin can neutralize the toxicities caused by muscarin, α - amanitin (a toxic substance found in Amanita Guibi), carbon tetrachloride, galactosamine, thioacetamide and liver virus FV3 in various pathological models of toxic liver damage.
The efficacy of silymarin is attributed to its several action points and mechanisms. Due to its ability to capture free radicals, silymarin has anti peroxidation activity. The pathophysiological process of lipid peroxidation (damage of cell membrane) can be blocked or prevented by silymarin. Moreover, silymarin stimulates protein synthesis and normalizes phospholipid metabolism in damaged hepatocytes. [3]
In conclusion, silymarin's greatest contribution is to stabilize the hepatocyte membrane. It prevents or avoids the loss of soluble cell components (such as transaminase). Silymarin can limit the penetration of some hepatotoxic substances (such as α - amanitin) into cells. The enhanced ability of protein synthesis is due to silymarin stimulating the activity of RNA polymerase I in the nucleus, which helps the synthesis of ribosomal RNA in hepatocytes and leads to the synthesis of structural and functional proteins (enzymes). Therefore, silymarin can enhance the repair ability and regeneration ability of hepatocytes.
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