Product Information:
| Product name |
Cefathiamidine for Injection |
| Specification |
0.5g, 1.0g, 2.0g |
| Package |
Customizable |
| Dosage |
Steriled Powder |
| Shelf life |
2 Years |
| Storage |
Cool and Dry place |
Indication:
It is used for respiratory system, hepatobiliary system, facial features, urinary tract infection, endocarditis and sepsis caused by sensitive bacteria.
Adverse reactions:
The main adverse reactions were urticaria, asthma, pruritus, chills and high fever, angioneurotic edema, etc. Occasionally, blood urea nitrogen, alanine aminotransferase and alkaline phosphatase increased after treatment. A few patients may have neutropenia, Candida, Staphylococcus and other double infection after medication.
Taboo:
It is forbidden to be allergic to cephalosporins. Patients with history of penicillin anaphylactic shock.
Matters needing attention:
1. Cross allergic reaction: before using this product, you should inquire about the drug allergy history of cephalosporins and penicillins in detail. If you are allergic to one cephalosporin or cephalamycin, you may also be allergic to other cephalosporins or cephalamycin. People who are allergic to penicillins, penicillin derivatives or penicillamine may also be allergic to cephalosporin or cephalosporin. When the patients allergic to penicillin were treated with cephalosporin, the incidence of allergic reaction was 1% - 7%; if the immune reaction was determined, the patients allergic to penicillin were sensitive to cephalosporin 20% were allergic.
2. The use of this product for patients with penicillin allergy should be based on the patient's situation. Allergic to penicillin
Cephalosporins should not be used in patients with shock or immediate reaction.
3. Patients with a history of gastrointestinal diseases, especially ulcerative colitis, localized colitis or antibiotic associated colitis (cephalosporins rarely produce pseudomembranous colitis), should be cautious.
4. The dosage of this product should be reduced in patients with renal insufficiency.
5. Interference to diagnosis: the patients who use this product may have positive Coombs test; the pregnant women who use this product prenatal may also have positive Coombs test in newborns.
6. The function of liver and kidney and Hemogram should be monitored during long-term medication.
Pharmacological action:
This product has antibacterial activity against Gram-positive bacteria and some negative bacteria, and has strong effect on Gram-positive bacteria. The antibacterial activity test in vitro showed that the product had strong antibacterial activity against pneumococcus, Streptococcus pyogenes, Staphylococcus aureus (MSSA), Staphylococcus epidermidis (MSSE) and cartabrandia. The mic 90 of the product was 0.25mg/ml against Streptococcus pneumoniae and 0.25mg/ml against the other three strains
The mic 90 of the bacteria was less than 8.0 mg / ml, and the mic 90 of the bacteria was 2.0 UG / ml against Haemophilus influenzae. It has good antibacterial activity against Streptococcus viridis, hemolytic streptococcus, non hemolytic streptococcus, Diphtheria Bacillus, Clostridium perfringens, tetanus bacillus and anthrax. The in vitro antibacterial activity against Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE) was lower than that of vancomycin. The mechanism of action of this product is to inhibit the synthesis of cell wall of sensitive bacteria and produce bactericidal effect.
Pharmacokinetics:
After intravenous drip of 1.0g, the Cmax was 68.93 ± 6.86mg/l, the T1 / 2 β was 1.19 ± 0.12h, the AUC was 94.7 ± 9.8me / (L · h), and the cumulative excretion rate of traditional Chinese medicine in urine was 93.1 ± 3.2%. After intramuscular injection of 1.0g, Cmax was 35.12 ± 4.34mg/l, the time to peak was 0.78 ± 0.08h, T1 / 2 β was 1.38 ± 0.21h, AUC was 85.3 ± 8.0mg / (L · h), and the cumulative excretion rate of traditional Chinese medicine in 12 hours urine was 84.2 ± 5.9%. Compared with intravenous drip, the absolute bioavailability of intramuscular injection was 90.3 ± 6.4%.
After injection, the drug is widely distributed in the body tissues, especially in bile, liver, kidney and lung, and does not penetrate the blood cerebrospinal fluid barrier. The plasma protein binding rate was about 23%. In the body almost no metabolism, mainly from the urine excretion, 12 hours urine excretion
More than 90% of the dosage. After intramuscular injection, the half-life of serum in patients with renal dysfunction was extended to 13.2 hours, which was about 10 times of the normal half-life. Only 3.2% of the dosage was excreted in 24 hours urine, and 20% - 30% of the dosage could be excreted in hemodialysis.
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