Product information;
| Product name |
Levofloxacin Tablets |
| Term of validity |
36 months |
| Storage |
Keep in dark and sealed |
Pharmacokinetics:
After oral administration, the drug was absorbed rapidly, and the plasma concentration reached the peak value 1-2 hours later. The absolute bioavailability of 500mg and 750mg was about 99%. Within the dose range, the pharmacokinetics of single or multiple oral or intravenous drip showed a linear relationship. 500 mg or 750 mg once a day reached steady state within 48 hours. The peak valley concentrations of 500 mg once a day were 5.7 ± 1.4 μ g / ml and 0.5 ± 0.2 μ g / ml, respectively, and the peak and valley concentrations of 750 mg once daily were 8.6 ± 1.9 μ g / ml and 1.1 ± 0.4 μ g / ml, respectively. The peak time was delayed by 1 hour and the peak concentration decreased by 14%. The changes of plasma concentration profile of the same dose of oral or intravenous drip are similar, so the intravenous and oral routes can be transformed into each other.
Pharmacological action:
This product is the levorotator of ofloxacin, and its antibacterial activity is about twice that of ofloxacin. Its main mechanism of action is to inhibit the activity of bacterial DNA gyrase (bacterial topoisomerase II) and hinder the replication of bacterial DNA.
This product has broad antibacterial spectrum and strong antibacterial effect. It has strong antibacterial activity against most Enterobacteriaceae bacteria, such as Escherichia coli, Klebsiella, Serratia, proteus, Shigella, Salmonella, Citrobacter, Acinetobacter, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae and so on. It also has good antibacterial effect on some gram-positive bacteria, such as methicillin sensitive Staphylococcus, Streptococcus pneumoniae, Streptococcus pyogenes, hemolytic streptococcus, Legionella, mycoplasma, chlamydia, but not to anaerobic bacteria and Enterococcus.
Matters needing attention:
1. Patients with renal insufficiency should reduce or extend the interval of administration, and those with severe renal insufficiency should use it with caution. The recommended dose adjustment scheme is as follows: (according to foreign data)
2. Patients with central nervous system diseases and epilepsy should be used with caution.
3. Quinolones can also cause rare phototoxicity (incidence < 0.1%). Avoid excessive sun exposure and artificial ultraviolet radiation when receiving this product. In case of photosensitive reaction or skin damage, the product should be stopped.
4. In case of allergy, the drug should be stopped immediately, and the following drugs or methods should be taken according to the specific clinical situation: epinephrine and other rescue measures, including oxygen inhalation, intravenous infusion, antihistamines, corticosteroids, etc.
5. Quinolones can also cause rare shock, allergic reaction, toxic epidermal necrosis, acute renal insufficiency, jaundice, agranulocytosis, leukopenia, hemolytic anemia, interstitial pneumonia, pseudomembranous colitis, etc.
6. In addition, there are occasional reports of rhabdomyolysis, hypoglycemia, Achilles tendon inflammation or rupture, mental disorder and allergic vasculitis after medication. Therefore, if the above symptoms occur, the drug should be stopped immediately and appropriate treatment should be carried out until the symptoms disappear.
7. Levofloxacin cannot be effectively eliminated by hemodialysis or peritoneal dialysis.
Taboo:
It is forbidden for those allergic to quinolones, pregnant and lactating women, and patients under 18 years old.
indication:
This product is suitable for the following mild and moderate infections caused by sensitive bacteria:
1. Respiratory system infection: acute sinusitis, acute attack of chronic bronchitis and community-acquired pneumonia;
2. Urinary system infection: acute pyelonephritis, complicated urinary tract infection, etc;
3. Reproductive system infection: prostatitis, epididymitis, intrauterine infection, adnexitis and pelvic inflammation (metronidazole can be used when anaerobic infection is suspected);
4. Skin and soft tissue infection: infectious pustulosis, cellulitis, lymphangitis, subcutaneous abscess, perianal abscess, etc;
5. Intestinal infection: bacillary dysentery, infectious enteritis, Salmonella enteritis, typhoid and paratyphoid, etc;
6. Other infections: trauma, burn and wound infection after operation, abdominal infection (combined with metronidazole if necessary), mastitis, cholecystitis, cholangitis, bone and joint infection, and infection of five sense organs.
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