Metoclopramide Hydrochloride for Injection GMP

• Application: Internal Medicine
• Usage Mode: I.M/I.V
• Suitable for: Elderly, Children, Adult
• State: Liquid
• Shape: Injection
• Type: Organic Chemicals
• Pharmaceutical Technology: Chemical Synthesis
• Drug Reg./Approval No.: Available
• Drug Ad Approval No.: Available
• Factory Inspection: Available
• Packing: Ampoules/Tray/Box
• OEM Service: Available
• MOQ: 5000
• Storage: Cool and Dry Place
• Quality Standard: Bp, USP
• Shelf Life: 36 Months
• Transport Package: Box/Carton
• Specification: 10mg, 2ml
• Trademark: Private logo service
• Origin: China
• Production Capacity: 100000000000PCS/Month

Product Description

Metoclopramide Hydrochloride  Injection

PRODUCT NAME:	Metoclopramide Hydrochloride  Injection
STRENGTH:	10mg,2ml
PACKING DETAILS:	10 ampoules/tray/box
STORAGE:	Store in a cool and dry place below 25ºC, protected from light.
SHELF LIFE:	36 months
REGISTRATION DOSSIERS ARE AVAILABLE.
CONSIGNMENT MANUFACTURING, BRAND OEM/ODM SERVICE IS AVAILABLE.

 

indication
Anti vomiting medicine.
(1) It is used for chemotherapy, radiotherapy, operation, brain injury, sequelae of brain injury, sea and air operation and vomiting caused by drugs;
(2) It is used for symptomatic treatment of nausea and vomiting of acute gastroenteritis, biliary tract and pancreas, uremia and other diseases;
(3) It can be used before diagnostic duodenal intubation, which is helpful for successful intubation; gastrointestinal barium X-ray examination can reduce nausea and vomiting reaction, and promote the passage of barium.


Usage and dosage
Intramuscular or intravenous injection. For adults, 10-20mg once a day, not more than 0.5mg/kg; for children, 0.1mg/kg once under 6 years old, 2.5-5mg once 6-14 years old. For renal insufficiency, the dosage should be halved.

Adverse reactions
(1) The common adverse reactions were drowsiness, restlessness, fatigue and weakness;
(2) The rare adverse reactions were: breast swelling and pain, nausea, constipation, rash, diarrhea, sleep disorders, dizziness, severe thirst, headache, irritability;
(3) The increase of milk was caused by the stimulation of prolactin;
(4) Injection can cause orthostatic hypotension;
(5) Long term application of large dose may cause extrapyramidal reaction (especially in young people) due to blocking dopamine receptor and hyperactivity of cholinergic receptor, which may lead to muscle tremor, dysphonia, ataxia, etc. it can be treated with anticholinergic drugs such as benhexol.

taboo
1. Disabled in the following cases:
(1) Allergic to procaine or procaine amine;
(2) The frequency and severity of epileptic seizures can be increased by medication;
(3) Gastrointestinal bleeding, mechanical intestinal obstruction or perforation may increase the gastrointestinal motility and aggravate the disease;
(4) Pheochromocytoma may have hypertensive crisis due to medication;
(5) It can not be used in breast cancer patients who vomit due to chemotherapy and radiotherapy.

2. Use with caution:
(1) In liver failure, it lost the ability of binding protein;
(2) Renal failure, that is, severe chronic renal failure, can increase the risk of extrapyramidal reaction, and the dosage should be reduced.
matters needing attention
(1) No effect on vomiting caused by motion sickness;
(2) The concentration of aldosterone and prolactin in serum increased with the use of metoclopramide;
(3) Patients with severe renal insufficiency need to reduce the dose by at least 60%, which is prone to extrapyramidal symptoms;
(4) Intravenous injection of metoclopramide should be slow, 1-2 minutes after injection, rapid administration can lead to restlessness, and then into a sleepy state;
(5) Because this product can reduce the oral bioavailability of cimetidine, if the two drugs must be combined, the interval should be at least 1 hour;
(6) When the product turns yellow or yellowish brown under light, its toxicity increases.
(7) In case of discoloration, crystallization, turbidity, foreign matter should be banned.