Product information:
| Producti name |
Folic Acid Tablets |
| Character |
This product is yellow or orange tablet. |
| Specifications |
5mg |
| Storage |
Protect from light and seal. |
| Term of validity |
24 months |
Pharmacology and toxicology:
Folic acid is a water-soluble B vitamin consisting of the residues of pteridine, p-aminobenzoic acid and glutamic acid, which is essential for cell growth and reproduction.It is found in the liver, kidney, yeast and green leafy vegetables such as beans, spinach, tomatoes, carrots, etc., and can now be synthesized artificially.Folic acid, through the action of dihydrofolate reductase and vitamin B12, forms tetrahydrofolate (THFA), which combines with a variety of one-carbon units (including CH3, CH2, CHO, etc.) to form tetrahydrofolate-like coenzymes, transfers one-carbon units, and participates in many important reactions in the body and the synthesis of nucleic acids and amino acids.Under the action of serine transhydroxylase, THFA forms N5,10-methenyltetrahydrofolate, which can promote the formation of thymidine nucleotide (dTMP) from uracil nucleotide (dUMP), which can participate in DNA synthesis of cells and promote cell division and maturation.During DNA synthesis, deoxyuridine is converted to deoxythymidylate, in which the required methyl group is provided by methylenetetrahydrofolate.When folic acid is deficient, DNA synthesis slows down, but RNA synthesis is unaffected. As a result, blood cells with larger volume of germ cells and more immature nuclei develop in bone marrow, especially red blood cells. Timely supplementation can have therapeutic effects.
Pharmacokinetics:
After oral administration, it is mainly absorbed in the proximal jejunum in a reduced form. It appears in blood in 5-20 minutes and reaches a peak one hour later. Its t1/2 is about 0.7 hours.Anemia patients absorb faster than normal people.Folic acid enters the liver from the portal vein, is stored in the liver in the form of N5-methyltetrahydrofolate and distributed to other tissues and organs, and is stored in the liver in about 1/3-1/2 of the total body volume.About 90% of the treated folic acid is excreted in the urine, and 20%-30% occurs in the urine 2 hours after high dose injection.
Matters needing attention:
1. Intravenous injection is easy to cause adverse reactions, so it should not be used; intramuscular injection should not be injected with vitamin B1, vitamin B2, vitamin C in the same tube.
2. Oral administration of large doses of folic acid can affect the absorption of trace element zinc.
3. Reuse the drug after the diagnosis is clear.If it is an experimental treatment, oral administration of 0.5 mg physiological dose per day should be used.
4. Nutritional megaloblastic anemia is often accompanied by iron deficiency, which should be supplemented with iron, protein and other B vitamins.
5. Patients with pernicious anemia and suspected vitamin B12 deficiency should not use folic acid alone, because this will increase the burden of vitamin B12 and neurological symptoms.
6. Maintenance therapy is generally not required unless it is a malabsorbed patient.
Adverse Reactions:
Adverse reactions were less frequent and allergic reactions were rare.Long-term medication can cause gastrointestinal symptoms such as food intolerance, nausea, abdominal distension, etc.When folic acid is taken in large quantities, the urine turns yellow.
Indication:
1. Folic acid deficiency caused by various reasons and megaloblastic anemia caused by folic acid deficiency.
2. Preventive Administration for pregnant and lactating women.
3. Folic acid deficiency caused by chronic hemolytic anemia.
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