Product Information:
| Product name |
Lincomycin hydrochloride injection |
| Specification |
0.6g:2ml |
| Packing |
Customizable |
| Standard |
BP. USP. |
| Shelf life |
2 Years |
| Sample |
Available |
Indication:
This product is suitable for respiratory tract infection, skin soft tissue infection, female genital tract infection, pelvic infection and abdominal infection caused by sensitive Staphylococcus, Streptococcus, Streptococcus pneumoniae and anaerobic bacteria. The latter two diseases can be used alone or combined with other antimicrobial agents according to the situation. In addition, patients with penicillin indications, such as patients who are allergic to penicillin or who are not suitable for penicillin, can be used as an alternative drug.
Usage and dosage:
Intramuscular injection: 0.6-1.2g per day for adults and 10-20mg / kg per day for children.
Intravenous drip: 0.6g for adults, once every 8 hours or 12 hours, every 0.6g dissolved in 100-200ml infusion, drip for 1-2 hours. The weight of children was 10-20 mg / kg per day. It should be noted that every 0.6g solution should be dissolved in not less than 100ml solution, and the infusion time should not be less than 1 hour. Not for infants less than 4 weeks old.
Adverse reactions:
1. The symptoms of severe diarrhea (including fever, colitis, pseudoperitonitis, etc.) may occur in the first few weeks after drug withdrawal.
2. Blood system: leucopenia, neutropenia, neutropenia and thrombocytopenia may occur occasionally. Aplastic anemia is rare.
3. Allergic reaction: rash, pruritus, urticaria, angioneurotic edema and serological reaction were seen occasionally. There were few reports of epidermal exfoliation, bullous dermatitis, erythema multiforme and S-J syndrome.
4. There are occasional reports of jaundice caused by the use of this product.
5. Hypotension, ECG changes, even cardiac arrest and respiratory arrest may occur during rapid infusion of this product.
6. Intravenous administration can cause thrombophlebitis.
Taboo:
It is forbidden to use lincomycin and clindamycin in patients with allergic history. This product contains benzoic acid. It is forbidden to be used for intramuscular injection in children.
Matters needing attention:
1. When allergic to this product, it may also be allergic to clindamycin.
2. Interference to diagnosis: serum alanine aminotransferase and aspartate aminotransferase may increase after taking medicine.
3. The following situations should be used with caution:
(1) Intestinal disease or history, especially ulcerative colitis, localized colitis or antibiotic pun enteritis (this product can cause pseudomembranous enteritis).
(2) Liver function decreased.
(3) The renal function decreased seriously.
4. Close attention should be paid to the frequency of defecation during medication. If the frequency of defecation increases, attention should be paid to the possibility of pseudomembranous enteritis, and the drug should be stopped in time and treated properly.
5. In order to prevent the occurrence of acute rheumatic fever, the course of treatment with this kind of drugs for hemolytic streptococcus infection should be at least 10 days.
6. Treatment of pseudomembranous enteritis caused by this product, mild patients may recover after drug withdrawal, moderate to severe patients need to correct water and electrolyte disorders. If there is no obvious improvement after the above treatment, metronidazole 250-500mg should be taken orally, three times a day. If the relapse occurs, metronidazole can be taken orally again, but it is still effective. If it is still ineffective, vancomycin (or norvancomycin) can be taken orally. Adults take 0.5-2.0g daily, three to four times.
7. Occasionally, it will lead to the over reproduction of insensitive microorganisms or double infection. Once double infection occurs, corresponding measures should be taken.
8. Use with caution if you have asthma or other allergic history.
9. If the course of treatment is long, the liver and kidney function and blood routine should be tested regularly.
Pharmacology and Toxicology:
This product has high antibacterial activity against common aerobic gram positive bacteria, such as Staphylococcus aureus (including penicillin G-resistant), Staphylococcus epidermidis, beta hemolytic streptococcus, Streptococcus viridis and Streptococcus pneumoniae. It has good antibacterial effect on anaerobes, including tetanus, Corynebacterium diphtheriae and Clostridium perfringens. It has no activity against gram negative bacteria and fungi such as Enterococcus, meningococci, Neisseria gonorrhoeae and Haemophilus influenzae. There was no cross resistance with penicillin, chloramphenicol, cephalosporins and tetracyclines, but partial cross resistance with macrolides. This product acts on the 50S subunit of ribosome of sensitive bacteria to prevent the extension of peptide chain, thus inhibiting the protein synthesis of bacterial cells. It is generally an antibacterial agent, but it also has bactericidal effect on some bacteria at high concentration.
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