High Quality Sodium Bicarbonate Injection 0.5g 10ml

• Customization: Available
• Application: Internal Medicine
• Usage Mode: I.M/I.V
• State: Liquid
• Shape: Injection
• Type: Organic Chemicals
• Pharmaceutical Technology: Chemical Synthesis
• Drug Reg./Approval No.: Available
• Drug Ad Approval No.: Available
• Factory Inspection: Available
• Packing: Ampoules/Tray/Box
• OEM Service: Available
• MOQ: 5000
• Quality Standard: USP/Cp
• Shelf Life: 3 Years
• Storage: Keep From Light
• Transport Package: Box/Carton
• Specification: 10ml: 0.5g
• Trademark: Private logo service
• Origin: China
• Production Capacity: 100000000000PCS/Month

Product Description

Sodium bicarbonate injection 
 

PRODUCT NAME	Sodium Bicarbonate Injection
Molecular Formula	NaHCO3
Molecular Weight	84.01
Appearance	colorless clear liquid
Specification	10ml:0.5g
Standard	USP/Cp
Colour	Colourless
CONSIGNMENT MANUFACTURING, BRAND OEM/ODM SERVICE IS AVAILABLE.

 

Indications
1. Treatment of metabolic acidosis. Treatment of mild to moderate metabolic acidosis, oral administration is appropriate. Severe metabolic acidosis should be intravenous infusion, such as severe kidney disease, circulatory failure, cardiopulmonary resuscitation, cardiopulmonary bypass and severe primary lactic acidosis, diabetic ketoacidosis and so on.
2. Alkaline urine. For the prevention of uric acid kidney stones, reduce the renal toxicity of sulfa drugs, and acute hemolysis to prevent hemoglobin deposition in the renal tubules.
3. As an antacid, treat symptoms caused by hyperacidity.
4. Intravenous infusion has non-specific therapeutic effects on certain drug poisonings, such as barbiturates, salicylates and methanol poisoning. However, this product is contraindicated in the gastric lavage when swallowing strong acidosis, because this product reacts with strong acid to produce a large amount of carbon dioxide, resulting in acute gastric dilatation and even gastric rupture.
Dosage
Metabolic acidosis, intravenous drip, the required dose is calculated by the following formula: amount of supplemental alkali (mmol) = (-2.3 - actual measured BE value) × 0.25 × body weight (kg), or the amount of alkali (mmol) = Normal CO2CP - Actual measured CO2CP (mmol) x 0.25 x body weight (kg). Unless the body loses bicarbonate, it is generally given 1/3 to 1/2 of the calculated dose, and the infusion is complete within 4 to 8 hours. When the cardiopulmonary resuscitation was performed, the first time was 1mmol/kg, and the amount was adjusted according to the results of blood gas analysis (equal to 12mmol of bicarbonate per 1g of sodium bicarbonate). Intravenous drugs should also pay attention to the following issues: (1) the range of intravenous application of the concentration of 1.5% (isotonic) to 8.4%; (2) should start from a small dose, according to the blood pH, bicarbonate concentration changes determine the additional dose; (3) A large number of intravenous infusions in a short period can cause severe alkalosis, hypokalemia, and hypocalcemia. When the amount exceeds 10 ml per minute hypertonic solution can cause hypernatremia, decreased cerebrospinal fluid pressure or even intracranial hemorrhage, which is more likely to occur in neonates and children under 2 years of age. Therefore, when infused with a 5% solution, the speed should not exceed 8 mmol sodium per minute. However, due to fatal acidosis during CPR, rapid intravenous infusion should be performed. Alkaline urine, adult: Oral 4g for the first time, 1-2g every 4 hours thereafter. Intravenous drip, 2~5mmol/kg, infusion completed within 4~8 hours. Pediatric: Oral, daily weight 1-10 mmol/kg.
Adverse reactions
1. A large number of intravenous injections can cause arrhythmia, muscle cramps, pain, abnormal fatigue and weakness, etc., mainly due to hypokalemia caused by metabolic alkalosis.
2. When the dose is too large or there is renal insufficiency, there may be edema, psychiatric symptoms, muscle pain or convulsions, breathing, oral odor, abnormal fatigue and weakness. Mainly caused by metabolic alkalosis.
3. May cause frequent urination, urgency, persistent headaches, loss of appetite, nausea and vomiting, abnormal fatigue, weakness, etc. during long-term use.
Contraindication 
Still uncertain.
Precautions
1. Interference with diagnosis: There is a significant effect on gastric acid secretion test or blood and urine pH measurements.
2. Use caution in the following situations:
(1) Oliguria or anuria due to increased sodium load;
(2) sodium retention and edema, such as cirrhosis, congestive heart failure, renal insufficiency, pregnancy-induced hypertension syndrome;
(3) Primary hypertension may be aggravated by increased sodium load.
3. Do not use intravenous drugs in the following situations:
(1) metabolic or respiratory alkalosis;
(2) Metabolic alkalosis is highly likely to occur due to vomiting or sustained gastrointestinal negative pressure attraction resulting in massive chlorine loss;
(3) Hypocalcemia may aggravate hypocalcemia due to alkalosis caused by this product.