Product information:
| Product name |
Metronidazole Tablets |
| Storage |
Dry Cool Place |
| Term of validity |
24 months |
| Specifications |
200mg/250mg/400mg/500mg |
Pharmacology and toxicology:
This product is a nitroimidazole derivative, which can inhibit the redox reaction of amoeba protozoa and break the nitrogen chain of protozoa.In vitro tests showed that when the drug concentration was 1-2 mg/L, histolytic amoeba could undergo morphological changes within 6-20 hours, and all were killed within 24 hours. When the drug concentration was 0.2 mg/L, histolytic amoeba could be killed within 72 hours.This product has a strong killing effect against trichomonas, and its mechanism is unknown.
Metronidazole has a killing effect on anaerobic microorganisms, and its metabolites generated during reduction in human body also have an anti-anaerobic effect, inhibiting the synthesis of deoxyribonucleic acid of bacteria, thereby interfering with the growth and reproduction of bacteria, and ultimately causing bacterial death.
Pharmacokinetics:
After oral or rectal administration, the drug can be rapidly and completely absorbed with a protein binding rate of [5%]. After absorption, it is widely distributed in various tissues and body fluids, and can pass the blood-brain barrier. The effective concentration of the drug can appear in saliva, placenta, bile, milk, amniotic fluid, semen, urine, pus and cerebrospinal fluid.It has been reported that the concentration of drugs in placenta, milk and bile is similar to that in blood.The blood drug concentration in cerebrospinal fluid of healthy people was 43% of that in the same period.In a few patients with brain abscess, after taking 1.2-1.8 g daily, the drug concentration of pus (34-45 mg/L) was higher than that of blood (11-35 mg/L) in the same period.The drug concentration in the pus was above 8.5 mg/L after intraauricular infection.After oral administration, the plasma concentration reaches its peak at 1-2 hours, and the effective concentration can be maintained for 12 hours.After oral administration of 0.25g, 0.4g, 0.5g and 2g, the plasma drug concentrations were 6, 9, 12 and 40 mg/L, respectively.This product is excreted 60-80% by kidney, about 20% of prototype drug is excreted from urine, the rest is excreted from urine in the form of metabolites (25% is glucuronic acid conjugate, 14% is other metabolic conjugate), 10% is excreted with feces, and 14% is excreted from skin.
Indication:
It is used to treat intestinal and parenteral amoebiasis (such as amoebic liver abscess, pleural amoebiasis, etc.).It can also be used to treat Trichomonas vaginalis, hydatidosis, cutaneous leishmaniasis, dracunculiasis and other infections.It is also widely used in the treatment of anaerobic infections.
Adverse Reactions:
Adverse reactions occur in 15% to 30% of cases, and digestive tract reactions are the most common, including nausea, vomiting, loss of appetite, abdominal cramps, which generally do not affect treatment; nervous system symptoms include headache, dizziness, occasional paresthesia, limb numbness, ataxia, polyneuritis, etc., large doses can cause convulsions.A few cases occurred urticaria, flushing, pruritus, cystitis, dysuria, metallic taste in the mouth and leukopenia, which were reversible, and recovered spontaneously after drug withdrawal.
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