Amoxicillin and Clavulanate Potassium Tablets
General name: amoxicillin and Clavulanate Potassium Tablets
[ingredient] the compound preparation consists of amoxicillin and clavulanate potassium (4:1).
[properties] this product is a film coated tablet. After removing the coating, it appears white to light yellow. It tastes slightly bitter and has moisture inducing properties.
[indications] this product is suitable for various infections caused by sensitive bacteria, such as: 1. Upper respiratory tract infections: sinusitis, tonsillitis, pharyngitis, etc. Lower respiratory tract infection: acute bronchitis, acute attack of chronic bronchitis, pneumonia, lung abscess and bronchial infection. Urinary tract infection: cystitis, urethritis, pyelonephritis, prostatitis, pelvic inflammation, Neisseria gonorrhoeae, urinary tract infection and chancre. Skin and soft tissue infection: furuncle, abscess, cellulitis, wound infection, abdominal sepsis, etc. Other infections: otitis media, osteomyelitis, sepsis, peritonitis and postoperative infection. From ampicillin
[usage and dosage] for adults and children over 12 years old, generally one tablet each time, three times a day; in case of severe infection, the dosage can be doubled or according to the doctor's advice. Without reexamination, the continuous treatment period was no more than 14 days.
For patients with impaired renal function: Patients with impaired renal function (creatinine elimination rate > 30ml / min) generally do not require to reduce the dose; for patients with severe renal function impairment, patients with creatinine elimination rate < 30ml / min should appropriately reduce the dose and extend the administration interval.
Hemodialysis patients should take it once more after dialysis.
[adverse reactions] 1 common gastrointestinal reactions such as diarrhea, nausea and vomiting. Rash, especially in patients with infectious mononucleosis. Anaphylactic shock, drug fever and asthma can be seen. 4. Occasionally, elevated serum aminotransferase, increased eosinophils, decreased white blood cells and double infection caused by Candida or drug-resistant bacteria. Central nervous system: headache occasionally, insomnia, anxiety and abnormal behavior are rare. Attention should be paid to the possible adverse reactions of ampicillin antibiotics.
[contraindications] penicillin skin test positive reaction, allergic to this product and other penicillins and infectious mononucleosis patients are forbidden.
[note] 1 patients must take penicillin skin test before taking this product every time. 2. It should be used with caution for those allergic to cephalosporins, those with allergic diseases such as asthma, eczema, hay fever and urticaria, and those with severe liver dysfunction. There is cross allergy between this product and other penicillins and cephalosporins. In case of allergic reaction, stop using the product immediately and take corresponding measures. 4. The drug has complete cross resistance with ampicillin, and cross resistance with other penicillins and cephalosporins. The dosage of amoxicillin or the interval of administration should be adjusted according to the clearance rate of serum creatinine in patients with renal dysfunction; hemodialysis can affect the blood concentration of amoxicillin
[medication for special population] precautions for children:
Suspension is recommended for children weighing less than 40 kg. The metabolism of amoxicillin will be delayed due to the renal insufficiency of newborns and infants. In pediatric treatment, the dosage of amoxicillin should be reduced for infants less than three months old.
Precautions during pregnancy and lactation:
1. This product can pass through the placenta, the concentration of umbilical cord blood is 1 / 4 ~ 1 / 3 of maternal blood concentration, so it is forbidden for pregnant women. 2. This product can be secreted into the breast milk, which may sensitize the baby and cause diarrhea, rash, Candida infection, etc. Therefore, lactating women should be careful to use it or stop breastfeeding during medication.
Precautions for the elderly:
The dosage or interval should be adjusted according to the renal function in elderly patients.
[drug interaction] 1 aspirin, indomethacin, butazone and sulfanilamide can reduce the excretion of the drug in renal tubules, thus increasing the blood concentration of the drug, prolonging the blood elimination half-life (T1 / 2) and increasing the toxicity. The incidence of skin rash was significantly increased when the drug was combined with allopurinol, so it should be avoided. 3. This product is not suitable for use with acetaldehyde dehydrogenase inhibitors such as disulfiram. 4. The incidence of long-term sequelae is higher when the drug is combined with chloramphenicol in bacterial meningitis than when they are used alone. This product can stimulate the metabolism of estrogen or reduce its enterohepatic circulation, so it can reduce the effect of oral contraceptives. 6 chloramphenicol, erythromycin
[pharmacological action] amoxicillin is a compound preparation composed of amoxicillin and clavulanate potassium. Amoxicillin is a semi synthetic broad-spectrum penicillin antibiotic, which mainly acts on the reproduction stage of bacteria and acts by inhibiting the biosynthesis of cell wall mucopoeptides. It is effective for many gram positive bacteria and gram negative bacteria. Clavulanate potassium has a β - lactamase structure similar to that of penicillin, and it has only weak antibacterial activity. However, it can inactivate many enzymes produced by bacteria by blocking the active site of β - lactamase, especially for plasmid mediated β - lactamases (which are usually related to the change of resistance to penicillin and cephalosporin). The combination of amoxicillin and β - lactamase can protect amoxicillin from the hydrolysis damage of β - lactamase, so it is still effective against β - lactamase producing resistant bacteria,
[storage] sealed and stored in a cool, dark and dry place. Validity: 24 months
[Specification] 625mg
[package specification] 7S/ blister*2blisters/box.
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