Cefoperazone Sodium and Sulbactam Sodium Sterile Powder for Injection 0.5g/1.0g/1.5g/2.0g/3.0g with Good Quality

• Application: Anti Infection
• Usage Mode: I.M./I.V.
• Suitable for: Elderly, Children, Adult
• State: Solid
• Shape: Powder
• Type: Organic Chemicals
• Model NO.: CEFSAL
• Pharmaceutical Technology: Chemical Synthesis
• Drug Reg./Approval No.: Available
• Drug Ad Approval No.: Available
• Sample: Available
• Storage: Cool & Dry Place
• OEM: Available
• Shelf Life: 3 Years
• Transport Package: Vial/Box/Carton
• Specification: 0.5g/0.75g/1.5g/2.0g/3.0g
• Trademark: OEM
• Origin: China
• Production Capacity: 100000 Boxes/Day

Product Description

About Cefoperazone Sodium
A third generation cephalosporin antibiotic, Parenteral antibiotic.
Mechanism of Action of Cefoperazone Sodium
Cefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefoperazone inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefoperazone. It has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis
Onset of Action for Cefoperazone Sodium
Sudden
Duration of Action for Cefoperazone Sodium
12 hours
Half Life of Cefoperazone Sodium
2 hours
Side Effects of Cefoperazone Sodium
1.Pain after I.M. injection & thrombophlebitis after I.V. injection.
2.Rashes & allergic manifestation
3.Super infection
4.Pseudo membranous colitis
5.Nausea
6.Vomiting
7.Diarrhea
8.Elevated liver enzymes
9.Neutropenia
10.Hypoprothrombinemia

Contra-indications of Cefoperazone Sodium
1.Hypersensitivity to cephalosporins
2.Pseudo membranous colitis

Special Precautions while taking Cefoperazone Sodium
1.Renal impairment
2.Hepatic impairment
3 Patient allergic to penicillins
4.Neuromuscular disorders
5.Along with other nephrotoxic drugs

Pregnancy Related Information
Use with caution.
Old Age Related Information
May be used.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution.
Neonates: contraindicated
Indications for Cefoperazone Sodium
1.Meningitis
2.Biliary infections
3.Septicemia
4.Infections in immunocompromised patients
5.Urinary tract &genital tract infections
6.Surgical prophylaxis
7.Skin & soft tissue infections
8.Bone & Joint infections
9.Gonorrhea,
10.Peritonitis.

Interactions for Cefoperazone Sodium
Alcohol: Disulfiram like reaction upto 72 hours after cefoperazone intake.
Aminoglycosides (Gentamycin, Tobramycin): Nephrotoxicity of aminoglycosides potentiated.
Oral anticoagulants: Hypothrombinemic effect potentiated, bleeding complications may occur.
Bacteriostatic agents like Chloramphenicol: Decreases efficacy of Cefoperazone sodium.
Probenecid: Slows tubular excretion and this enhances efficacy.
Frusemide & Ethacrynic Acid: Potentiate nephrotoxicity of Cefoperazone Sodium.
Lab. Test: Urine Glucose: False positive with Benedicts solution and Fehlings solution.
Direct Coomb?s Test: False positive.
Urinary 17-Ketosteroid values: Falsely elevated values.


Typical Dosage for Cefoperazone Sodium
Adults: 1g to 2gm I.M. or I.V. two times daily to three times daily.
In severe infections: 12gm/day in two to four divided doses
Children: 50 to 200 mg/kg/day I.M or I.V. two times daily
In meningitis child dosage: Up to 300mg/kg/day
Maximum adult dose: Up to 12gm/day
Maximum child dose: 300mg/kg/day